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Volume 31 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(6): 409-411,435

MIAO Jie, WANG Ai-wu, YANG Liu, HUO Ran, XU Guang-qi. Preparation and quality control of propranolol hydrochloride cream[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 409-411,435. doi: 10.3969/j.issn.1006-0111.2013.06.003
Citation: MIAO Jie, WANG Ai-wu, YANG Liu, HUO Ran, XU Guang-qi. Preparation and quality control of propranolol hydrochloride cream[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 409-411,435. doi: 10.3969/j.issn.1006-0111.2013.06.003
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Preparation and quality control of propranolol hydrochloride cream

doi: 10.3969/j.issn.1006-0111.2013.06.003
  • 1.

    Shandong Traditional Chinese Medical University, Jinan 250355, China;Department of Pharmacy, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China

  • 2.

    Department of Pharmacy, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China

  • 3.

    Department of Burn-Plastic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China

  • 4.

    Department of Burn-Plastic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China;School of Medicine, Shandong University, Jinan 250100, China

  • Received Date: 2013-03-29
  • Rev Recd Date: 2013-09-23
  • Objective To optimize matrix formula and process conditions and control the quality of propranolol hydrochloride cream. Methods Emulsifying temperature, dosages of the stearic acid, glyceryl monostearate and Tween-80 were taken as variable factors and the orthogonal experiment was adopted to optimize matrix formula and process conditions. HPLC was chosen to determine the content of propranolol hydrochloride and control its quality. Results The optimized matrix formula of propranolol hydrochloride cream was composed of 10%of stearic acid, 7.5%of glyceryl monostearate, 3% of Tween-80 and emulsifying temperature was 70℃. The appearance and stability were good and the quality was good. The average recovery rate was 98.65%, RSD was 0.52% (n=9). Conclusion The preparation process of propranolol hydrochloride cream was rational and stable in quality. The quality control method was simple and fast.
  • [1] Léauté-Labrèze C, Dumas dela Roque E, Hubiche T, et al. Propranolol for severe hemangiomas of infancy[J]. N Engl J Med, 2008, 358(24):2649.
    [2] 金英姬,金哲虎,崔笑怡,等.普萘洛尔口服治疗婴幼儿血管瘤的临床观察[J].中国皮肤性病学杂志,2011,9(25):688.
    [3] 李喜.普萘洛尔口服治疗婴幼儿血管瘤的效果观察[J].山东医药,2011,51(34):103.
    [4] 张健.普萘洛尔在婴幼儿增生期血管瘤治疗中的临床应用[D].山东大学, 2010:9.
    [5] 毕殿洲.药剂学[M].4版.北京:人民卫生出版社,2000:369.
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Preparation and quality control of propranolol hydrochloride cream

doi: 10.3969/j.issn.1006-0111.2013.06.003
  • 1. Shandong Traditional Chinese Medical University, Jinan 250355, China;Department of Pharmacy, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • 2. Department of Pharmacy, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • 3. Department of Burn-Plastic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • 4. Department of Burn-Plastic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China;School of Medicine, Shandong University, Jinan 250100, China
  • Received Date: 2013-03-29
  • Rev Recd Date: 2013-09-23

Abstract: Objective To optimize matrix formula and process conditions and control the quality of propranolol hydrochloride cream. Methods Emulsifying temperature, dosages of the stearic acid, glyceryl monostearate and Tween-80 were taken as variable factors and the orthogonal experiment was adopted to optimize matrix formula and process conditions. HPLC was chosen to determine the content of propranolol hydrochloride and control its quality. Results The optimized matrix formula of propranolol hydrochloride cream was composed of 10%of stearic acid, 7.5%of glyceryl monostearate, 3% of Tween-80 and emulsifying temperature was 70℃. The appearance and stability were good and the quality was good. The average recovery rate was 98.65%, RSD was 0.52% (n=9). Conclusion The preparation process of propranolol hydrochloride cream was rational and stable in quality. The quality control method was simple and fast.

MIAO Jie, WANG Ai-wu, YANG Liu, HUO Ran, XU Guang-qi. Preparation and quality control of propranolol hydrochloride cream[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 409-411,435. doi: 10.3969/j.issn.1006-0111.2013.06.003
Citation: MIAO Jie, WANG Ai-wu, YANG Liu, HUO Ran, XU Guang-qi. Preparation and quality control of propranolol hydrochloride cream[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 409-411,435. doi: 10.3969/j.issn.1006-0111.2013.06.003
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