Synthesis and antifungal activities of new triazole compounds

PANG Tao; WU Mao-cheng; WANG Xiao-yi

doi:10.3969/j.issn.1006-0111.2013.05.016

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Objective To design and synthesis novel triazole antifungal derivatives and study the antifungal activity. Methods All the target compounds were prepared from 1,3-difluorobenzene via click reaction;The antibacterial activities of the title compounds were determined with broth dilution method. Results Twelve compounds were synthesized and characterized by 1H NMR and MS. All the title compounds exhibited potent antifungal activities against nearly all fungi tested. Conclusion The electronic effects of the substituents affected the activity of compounds, specifically the electron-donating groups.

Synthesis and antifungal activities of new triazole compounds

1. Department of pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

2. Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

3. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China

Received Date: 2013-03-12

Rev Recd Date: 2013-04-28

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Abstract: Objective To design and synthesis novel triazole antifungal derivatives and study the antifungal activity. Methods All the target compounds were prepared from 1,3-difluorobenzene via click reaction;The antibacterial activities of the title compounds were determined with broth dilution method. Results Twelve compounds were synthesized and characterized by 1H NMR and MS. All the title compounds exhibited potent antifungal activities against nearly all fungi tested. Conclusion The electronic effects of the substituents affected the activity of compounds, specifically the electron-donating groups.

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Synthesis and antifungal activities of new triazole compounds

doi: 10.3969/j.issn.1006-0111.2013.05.016

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通讯作者: 陈斌, [email protected]

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