CHEN Bing-yang, YUE Rong-cai, LIU Fang, LI Xia, LI Yuan-yuan, WU Guo-zhen, SHAN Lei. Acetophenones and antioxidant activity in Cynanchum auriculatum Royle ex Wight[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 351-354. doi: 10.3969/j.issn.1006-0111.2013.05.008
| Citation:
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CHEN Bing-yang, YUE Rong-cai, LIU Fang, LI Xia, LI Yuan-yuan, WU Guo-zhen, SHAN Lei. Acetophenones and antioxidant activity in Cynanchum auriculatum Royle ex Wight[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 351-354. doi: 10.3969/j.issn.1006-0111.2013.05.008
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Acetophenones and antioxidant activity in Cynanchum auriculatum Royle ex Wight
- Received Date: 2012-12-04
- Rev Recd Date:
2013-04-08
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Abstract
Objective To study the chemical constituents and antioxidant activityof the root tubers of Cynanchum auriculatum Royle ex Wight (asclepiadaceae). Methods The root tubers were extracted with 95% EtOH, and the ethanol extract was further separated and purified by repeated column chromatography of silica gel and Sephadex LH-20. Structures of the compounds were identified on the basis of spectral analysis (including NMR and MS) and chemical evidences. Results Five acetophenones were isolated from Cynanchum auriculatum Royle ex Wight. Their structures were characterized as cynandione A (I), cynandione B (II), cynandione C (III), cynanchone A (IV), cynantetrone (V). H2O2 decreases SOD, CAT and GSH-Px activities, while the acetophenones could inhibit H2O2-induced oxidative damage. Conclusion The acetophenones isolated from the root tubers of Cynanchum auriculatum Royle ex Wight possessed potent antioxidant activities.
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