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Volume 31 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(4): 290-292,299

PENG Xian-dong, LONG Feng, TANG Zhi-li, XIE Jun. Study on stability of tinidazole and spironolactone cream[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(4): 290-292,299. doi: 10.3969/j.issn.1006-0111.2013.04.014
Citation: PENG Xian-dong, LONG Feng, TANG Zhi-li, XIE Jun. Study on stability of tinidazole and spironolactone cream[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(4): 290-292,299. doi: 10.3969/j.issn.1006-0111.2013.04.014
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Study on stability of tinidazole and spironolactone cream

doi: 10.3969/j.issn.1006-0111.2013.04.014

  • Department of Pharmacy, Nanchong Municipal Central Hospital, Nanchong 637000, China

  • Received Date: 2012-07-16
  • Rev Recd Date: 2012-08-13
  • Objective To study the stability of tinidazole and spironolactone cream. Methods The content of tinidazole and spironolactone in cream were determined simultaneously by HPLC, and the period of validity of tinidazole spironolactone cream was predicted by accelerated test and long term test predictive validity. Results The content of tinidazole and spironolactone were decreasing gradually with the increasing of prolonging of time. After accelerated test, 6 months of tinidazole dropped 4.37%.spironolactone dropped 3.10%.After long term test, 12 months of tinidazole dropped 5.27%, spironolactone dropped 3.73%.Content and other indicators were in line with the provision. Conclusion The validity period of tinidazole and spironolactone was 12 months.
  • [1] 彭贤东,唐志立,龙凤,等.替硝唑螺内酯乳膏治疗寻常痤疮62例[J].中国药业,2010,19(17):77.
    [2] 中国药典2010版.二部[S].附录,2010:199.
    [3] 张雅稚,何标.复方替硝唑霜的制备及含量测定[J].中国医院药学杂志,2011,31(22):1908.
    [4] 王菊荣,王月军,叶勇,等.HPLC法测定复方药物微乳膏中螺内酯的含量[J].药物分析杂志,2006,26(12):1883.
    [5] 李超,张勉. HPLC法测定螺内酯片的含量[J].中国药房,2010,21(17):1610.
    [6] 彭贤东,唐志立,龙凤,等.替硝唑螺内酯乳膏的制备及质量控制[J].中国药业,2010,19(5):34.
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Study on stability of tinidazole and spironolactone cream

doi: 10.3969/j.issn.1006-0111.2013.04.014
  • Department of Pharmacy, Nanchong Municipal Central Hospital, Nanchong 637000, China
  • Received Date: 2012-07-16
  • Rev Recd Date: 2012-08-13

Abstract: Objective To study the stability of tinidazole and spironolactone cream. Methods The content of tinidazole and spironolactone in cream were determined simultaneously by HPLC, and the period of validity of tinidazole spironolactone cream was predicted by accelerated test and long term test predictive validity. Results The content of tinidazole and spironolactone were decreasing gradually with the increasing of prolonging of time. After accelerated test, 6 months of tinidazole dropped 4.37%.spironolactone dropped 3.10%.After long term test, 12 months of tinidazole dropped 5.27%, spironolactone dropped 3.73%.Content and other indicators were in line with the provision. Conclusion The validity period of tinidazole and spironolactone was 12 months.

PENG Xian-dong, LONG Feng, TANG Zhi-li, XIE Jun. Study on stability of tinidazole and spironolactone cream[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(4): 290-292,299. doi: 10.3969/j.issn.1006-0111.2013.04.014
Citation: PENG Xian-dong, LONG Feng, TANG Zhi-li, XIE Jun. Study on stability of tinidazole and spironolactone cream[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(4): 290-292,299. doi: 10.3969/j.issn.1006-0111.2013.04.014
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