The influence of butylphthalide on amino acid in epileptic mice's brain

HAN Lin

doi:10.3969/j.issn.1006-0111.2013.04.012

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Objective Aim to investigate the influence of butylphthalide (NBP) on amino acid content in epileptic mice's brain. Methods NBP was intraperitoneally injected (ip) mice and acute epileptic mice models were made after 30 min. The change of the four amino acid(aspartic acid, gamma-aminobutyric acid, glutamate, glycine) content in brain of epileptic mice was investigated. Results For NBP treated epileptic mice, when compared with model group, the contents of glutamate and glutamate/gamma-aminobutyric acid(model group:38.78;NBP hige dose group:5.52) were reduced (P<0.05) in brain of epileptic mice. Conclusion NBP could regulate the balance of excitement and inhibition systems which might relieve seizures.

The influence of butylphthalide on amino acid in epileptic mice's brain

Department of Pharmacy, Children's Hospital of Xuzhou, Xuzhou 221002, China

Received Date: 2012-10-07

Rev Recd Date: 2013-04-08

Key words:

NBP /
epilepsy /
amino acid

Abstract: Objective Aim to investigate the influence of butylphthalide (NBP) on amino acid content in epileptic mice's brain. Methods NBP was intraperitoneally injected (ip) mice and acute epileptic mice models were made after 30 min. The change of the four amino acid(aspartic acid, gamma-aminobutyric acid, glutamate, glycine) content in brain of epileptic mice was investigated. Results For NBP treated epileptic mice, when compared with model group, the contents of glutamate and glutamate/gamma-aminobutyric acid(model group:38.78;NBP hige dose group:5.52) were reduced (P<0.05) in brain of epileptic mice. Conclusion NBP could regulate the balance of excitement and inhibition systems which might relieve seizures.

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Reference (9)

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The influence of butylphthalide on amino acid in epileptic mice's brain

doi: 10.3969/j.issn.1006-0111.2013.04.012

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通讯作者: 陈斌, [email protected]

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