Analysis of the main pathogenic bacteria resistance rates and antibacterial drugs usage in our hospital in 2011

Key words: 
• antimicrobial drugs /
• DDDs /
• bacteria resistance /
• correlation

Abstract: Objective To analyze the main pathogenic bacteria resistance rates and antibacterial drugs usage in our hospital, and provide reference for the rational of antimicrobial drugs and management. Methods The SPSS13.0 software was used for statistical analysis of pathogenic bacteria drug resistance from the detected positive bacteria and its susceptibility test results in my hospital in 2011, combined with the annual antibiotics DDDs to analyze the rationality of antibacterial drug use. Results Among the positive samples were Gram-positive bacteria of 1927, accounting for 33.1% of the 5 822 cases. Separation of Gram-positive bacteria, Staphylococcus aureus accounted for in the first place(16.9%), followed by hemolytic Staphylococcus aureus(15.9%) and Staphylococcus epidermidis(14.1%).Methicillin-resistant Staphylococcus aureus(MRSA)(36.7%), methicillin-resistant coagulase-negative staphylococci(MRS-con)accounted for 82.5%, were resistant to all beta-lactam antibiotics, vancomycin, fusidic acid and teicoplanin better sensitivity, resistance rates did not exceed 6.47%;Gram-negative bacteria of 2 661, accounting for 45.7%, the separation of Gram-negative bacteria Enterobacteriaceae and non-fermenting bacteria, Escherichia coli, Enterobacteriaceae (23.5%), Klebsiella pneumoniae(15.6%)and Enterobacter cloacae(3.7%), Enterobacteriaceae inhibitor-containing piperacillin/tazobactam, cefoperazone/sulbactam are kept better sensitivity, resistance rates lower than 27.82%, amikacin rate of less than 14.36%;non-fermenting bacteria Pseudomonas aeruginosa(10.2%), calcium acetate Bowman Acinetobacter(7.9%) and Stenotrophomonas narrow mainly food Aeromonas.Non-fermenting bacteria to cefoperazone/sulbactam better sensitivity, resistance rates did not exceed 29.44%;Resistance to quinolones rate of more than 31.39%;third and fourth generation cephalosporin resistance rates of non-fermenting bacteria more than 35.19%;imipenem resistant Acinetobacter baumannii rate of 81.32%.The most bacterial resistance rates with the use of antibiotics strength was positively correlated(r>0.3, P<0.05). Conclusion Bacterial drug resistance situation was more serious in my hospital.The use and management of antibiotics should be strengthened as soon as possible, and drugs should be selected according to clear pathogens andantimicrobial susceptibility test to reduce drug resistant bacteria produce.