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Volume 31 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(3): 215-216,223

YUAN Chang-zheng. Low dose of dexmedetomidine combined with propofol in endoscopic submucosal dissection[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 215-216,223. doi: 10.3969/j.issn.1006-0111.2013.03.016
Citation: YUAN Chang-zheng. Low dose of dexmedetomidine combined with propofol in endoscopic submucosal dissection[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 215-216,223. doi: 10.3969/j.issn.1006-0111.2013.03.016
shu

Low dose of dexmedetomidine combined with propofol in endoscopic submucosal dissection

doi: 10.3969/j.issn.1006-0111.2013.03.016

  • The first people hospital of Xiangshan, Xiangshan 315700, China

  • Received Date: 2012-10-17
  • Rev Recd Date: 2013-04-08
  • Objective To evaluate the effect and safety of low dose of dexmedetomidine combined with propofol used in endoscopic submucosal dissection (ESD). Methods 80 ASAⅠ~Ⅱ level patients in need of ESD were selected and randomly divided into 2 groups:Group P was given propofol; Group M was given low dose of dexmedetomidine combined with propofol. The following data were recorded:blood-pressure, cardiac rate at each point during anesthesia, the time of operation and tracheal extubation and palinesthesia, propofol and Fentanyl dosage, and adverse reaction. Results There was no significant difference in the time of operation between the two groups; compared with the P group, the dosage of propofol in M group is less, stable hemodynamics, the time of tracheal extubation and palinesthesia were shorter with less adverse reactions(P<0.05). Conclusion The anesthetic effect of low dose of dexmedetomidine combined with propofol in ESD was satisfactory and safe.
  • [1] Rosch T,Sarbia M,Schumacher B,et al.Attempted endoscopic enbloc resection of mucosal and Submucosaltumors using insulated-tip knives:a pilot series[J].Endoscopy, 2004, 36:788.
    [2] Gotoda T,Friedland S,Hamanaka H,et al.A learningcurve for advarced endoscopic resection[J].Gastrointest Endosc, 2005, 62:866.
    [3] 于舒洋.氟比洛芬用于无痛人工流产术疗效及安全性的临床研究[J].实用药物与临床,2011,14(2):92.
    [4] 胡宪文,张野,孔令锁,等.不同剂量右美托咪定抑制气管插管诱发患者心血管反应效应的比较[J].中华麻醉学杂志,2010,30(11):1034.
    [5] Chrysostomou C,Schmit CG.Dexmedetomicdine:sedation, analgesia and beyond[J].Expert Opin Drug Metab Toxicol,2008,4(5):619.
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Low dose of dexmedetomidine combined with propofol in endoscopic submucosal dissection

doi: 10.3969/j.issn.1006-0111.2013.03.016
  • The first people hospital of Xiangshan, Xiangshan 315700, China
  • Received Date: 2012-10-17
  • Rev Recd Date: 2013-04-08

Abstract: Objective To evaluate the effect and safety of low dose of dexmedetomidine combined with propofol used in endoscopic submucosal dissection (ESD). Methods 80 ASAⅠ~Ⅱ level patients in need of ESD were selected and randomly divided into 2 groups:Group P was given propofol; Group M was given low dose of dexmedetomidine combined with propofol. The following data were recorded:blood-pressure, cardiac rate at each point during anesthesia, the time of operation and tracheal extubation and palinesthesia, propofol and Fentanyl dosage, and adverse reaction. Results There was no significant difference in the time of operation between the two groups; compared with the P group, the dosage of propofol in M group is less, stable hemodynamics, the time of tracheal extubation and palinesthesia were shorter with less adverse reactions(P<0.05). Conclusion The anesthetic effect of low dose of dexmedetomidine combined with propofol in ESD was satisfactory and safe.

YUAN Chang-zheng. Low dose of dexmedetomidine combined with propofol in endoscopic submucosal dissection[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 215-216,223. doi: 10.3969/j.issn.1006-0111.2013.03.016
Citation: YUAN Chang-zheng. Low dose of dexmedetomidine combined with propofol in endoscopic submucosal dissection[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 215-216,223. doi: 10.3969/j.issn.1006-0111.2013.03.016
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