Clinical effects and blood concentration of vancomycin:32 cases report

CHENG Shu-min; TIAN Wen-yuan; ZHANG Jie; BIAN Meng

doi:10.3969/j.issn.1006-0111.2013.03.012

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Objective To evaluate clinical utilization and blood concentration monitoring of vancomycin in our hospital and offer reference to reasonable clinical use of drugs. Methods The clinical information (primary diseases, bacteriological culture, blood concentration of vancomycin, clinical efficacy, renal function) of 32 inpatients who had been treated with vancomycin and their blood concentrations from Dec. 2011 to Apr. 2012 were analyzed statistically. Results The bacteria detection rate was 53%. The drug indications bacteriology coincidence rate was 31%. The total response rate of vancomycin was 68.75%. The valley values of 25% cases were between 10 mg/L and 20 mg/L. The incidence of renal dysfunction after treatment was 12.5%. Conclusion The valley value of blood concentration of the 32 cases using vancomycin that first measured were less in effective range which should be paid attention to the blood concentration monitoring of agedness patients to achieve an ideal individual administration according to clinical practice.

Clinical effects and blood concentration of vancomycin:32 cases report

The Affiliated Fuxing Hospital of Shoudu Medical University, Beijing 100038 China

Received Date: 2012-07-02

Rev Recd Date: 2012-09-11

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Abstract: Objective To evaluate clinical utilization and blood concentration monitoring of vancomycin in our hospital and offer reference to reasonable clinical use of drugs. Methods The clinical information (primary diseases, bacteriological culture, blood concentration of vancomycin, clinical efficacy, renal function) of 32 inpatients who had been treated with vancomycin and their blood concentrations from Dec. 2011 to Apr. 2012 were analyzed statistically. Results The bacteria detection rate was 53%. The drug indications bacteriology coincidence rate was 31%. The total response rate of vancomycin was 68.75%. The valley values of 25% cases were between 10 mg/L and 20 mg/L. The incidence of renal dysfunction after treatment was 12.5%. Conclusion The valley value of blood concentration of the 32 cases using vancomycin that first measured were less in effective range which should be paid attention to the blood concentration monitoring of agedness patients to achieve an ideal individual administration according to clinical practice.

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Reference (6)

[1]	黄仲义,肖永红,张菁.万古霉素临床应用中国专家共识(2011版)[J].中国新药与临床杂志,2011,30(8):561.
[2]	刘振声,金大鹏,陈增辉.医院感染管理学[M].北京:军事医学科学出版社,2008:328.
[3]	王爱霞,范洪伟,吕玮,等.桑福德抗微生物治疗指南(新译第41版)2011-2012[M].北京:中国协和医科大学出版社,2011:39.
[4]	Liu C,Bayer A,Cosgrove SE,et al.Clinical practice guidelines by the infectious diseases society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children[J].Clin infect Dis,2011,52(3):e18.
[5]	Rybak M,Lomaestro B,Rotschafer JC,et al.Therapeutic monitoring of vancomycin in adult patients:a consensus review of the American Society of Health-System Pharmacists,the Infectious Diseases Society of America,and the Society of Infectious Diseases Pharmacists[J].Am J Health Syst pharm,2009,66:82.
[6]	Rybak MJ.The pharmacokinetic and pharmacodynamic properties of vancomycin[J].Clin Infect Dis,2006,42(Suppl.1):S35

[1]	黄仲义,肖永红,张菁.万古霉素临床应用中国专家共识(2011版)[J].中国新药与临床杂志,2011,30(8):561.
[2]	刘振声,金大鹏,陈增辉.医院感染管理学[M].北京:军事医学科学出版社,2008:328.
[3]	王爱霞,范洪伟,吕玮,等.桑福德抗微生物治疗指南(新译第41版)2011-2012[M].北京:中国协和医科大学出版社,2011:39.
[4]	Liu C,Bayer A,Cosgrove SE,et al.Clinical practice guidelines by the infectious diseases society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children[J].Clin infect Dis,2011,52(3):e18.
[5]	Rybak M,Lomaestro B,Rotschafer JC,et al.Therapeutic monitoring of vancomycin in adult patients:a consensus review of the American Society of Health-System Pharmacists,the Infectious Diseases Society of America,and the Society of Infectious Diseases Pharmacists[J].Am J Health Syst pharm,2009,66:82.
[6]	Rybak MJ.The pharmacokinetic and pharmacodynamic properties of vancomycin[J].Clin Infect Dis,2006,42(Suppl.1):S35

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Clinical effects and blood concentration of vancomycin:32 cases report

doi: 10.3969/j.issn.1006-0111.2013.03.012

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通讯作者: 陈斌, [email protected]

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