Tissue distribution of astilbin in mice

LI Yu-qi; GU Jin; HUAN Zheng; QIU Jin; LI Yu-lian; DENG Chang-guo

doi:10.3969/j.issn.1006-0111.2013.03.011

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Objective To establish a high performance capillary electrophoresis(HPCE) method for analysis of tissue distribution of astilbin in mice. Methods The model of micellar electrokinetic capillary chromatography(MECC) of HPCE was adopted after intravenous injection.The concentrations of astilbin in biological samples were determined. Results The tissue distribution feature of astilbin was C_heart > C_liver > C_kidney > C_spleen > C_lung > C_brain. The Cheart shows C_{5 min} > C_{15 min} > C_{60 min} and C_{5 min} is C_max. But C_{15 min} was C_max in other tissues. The steady content of astilbin was found in brain tissue within 60 min. Conclusion Astilbin was widely distributed in main tissues, which could also permeate blood brain barrier.

Tissue distribution of astilbin in mice

1. Department of Pharmacy, Shanghai Yangpu District Central Hospital, Shanghai 200090, China

2. Urumqi general Hospital, Lanzhou Millitary Region of PLA, Urumqi 830000, China

Received Date: 2012-10-16

Rev Recd Date: 2012-12-28

Key words:

astilbin /
high performance capillary electrophoresis(HPCE) /
tissue distribution

Abstract: Objective To establish a high performance capillary electrophoresis(HPCE) method for analysis of tissue distribution of astilbin in mice. Methods The model of micellar electrokinetic capillary chromatography(MECC) of HPCE was adopted after intravenous injection.The concentrations of astilbin in biological samples were determined. Results The tissue distribution feature of astilbin was C_heart > C_liver > C_kidney > C_spleen > C_lung > C_brain. The Cheart shows C_{5 min} > C_{15 min} > C_{60 min} and C_{5 min} is C_max. But C_{15 min} was C_max in other tissues. The steady content of astilbin was found in brain tissue within 60 min. Conclusion Astilbin was widely distributed in main tissues, which could also permeate blood brain barrier.

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Reference (12)

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Tissue distribution of astilbin in mice

doi: 10.3969/j.issn.1006-0111.2013.03.011

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通讯作者: 陈斌, [email protected]

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