Clinical efficacy of Jiangtang Mixture on diabetic peripheral Neuropathy

HUANG Qiu-ming; ZHAO Tao

doi:10.3969/j.issn.1006-0111.2013.02.012

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Objective To evaluate the efficacy and explore the mechanism of Jiangtang Mixture in treatment of diabetic peripheral neuropathy (DPN). Methods 60 cases of DPN patients were randomly divided into treatment group and control group with 30 cases in each group. Two groups were all treated with a diet control, routine hypoglycemic therapy, the control group was treated with Methylcobalamin Tablet 0.5 mg, po, tid. While the treatment group was treated with Jiangtang Mixture 50 ml, po, tid, on the basis of the control group. The course of treatment was 4 weeks in each group. Before and after treatment, clinical signs and symptoms were observed and determined, including fasting plasma glucose (FPG), the 2 hours postprandial blood glucose (PPG_2h), glycated hemoglobin (HbA_1C), plasma viscosity (PV), endothelin (ET), nitric oxide (NO), and nerve conduction velocity (NCV). Results The total effective rate of the treatment group (86.67%) was significantly higher than that of the control group (63.33%)(P<0.05). There were significant differences in levels of the indexes, such as NCV、FPG、PPG_2h、HbA_1C、PV、ET and NO in the treatment group before and after treatment (P<0.05), but only in the four indexes, such as NCV、PV、ET and NO, the treatment group compared with the control group showed significantly differences after treatment (P<0.05). Adverse reactions of Jiangtang Mixture did not find in the observation period. Conclusion Jiangtang Mixture combined with Mecobalamine to treat DPN was safe and effective. The mechanism could be related to protect vascular endothelial cell, improve blood rheology, expand the peripheral microvascular, nourish the nerve with blood and oxygen supply, prevent or reverse impaired peripheral nerve fibers of DPN.

Clinical efficacy of Jiangtang Mixture on diabetic peripheral Neuropathy

1. School of Medicine, Wuhan University, Wuhan 430071, China;Xiaogan Centre Hospital, Xiaogan 432000, China

2. Xiaogan Centre Hospital, Xiaogan 432000, China

Received Date: 2012-09-18

Rev Recd Date: 2012-11-06

Key words:

Abstract: Objective To evaluate the efficacy and explore the mechanism of Jiangtang Mixture in treatment of diabetic peripheral neuropathy (DPN). Methods 60 cases of DPN patients were randomly divided into treatment group and control group with 30 cases in each group. Two groups were all treated with a diet control, routine hypoglycemic therapy, the control group was treated with Methylcobalamin Tablet 0.5 mg, po, tid. While the treatment group was treated with Jiangtang Mixture 50 ml, po, tid, on the basis of the control group. The course of treatment was 4 weeks in each group. Before and after treatment, clinical signs and symptoms were observed and determined, including fasting plasma glucose (FPG), the 2 hours postprandial blood glucose (PPG_2h), glycated hemoglobin (HbA_1C), plasma viscosity (PV), endothelin (ET), nitric oxide (NO), and nerve conduction velocity (NCV). Results The total effective rate of the treatment group (86.67%) was significantly higher than that of the control group (63.33%)(P<0.05). There were significant differences in levels of the indexes, such as NCV、FPG、PPG_2h、HbA_1C、PV、ET and NO in the treatment group before and after treatment (P<0.05), but only in the four indexes, such as NCV、PV、ET and NO, the treatment group compared with the control group showed significantly differences after treatment (P<0.05). Adverse reactions of Jiangtang Mixture did not find in the observation period. Conclusion Jiangtang Mixture combined with Mecobalamine to treat DPN was safe and effective. The mechanism could be related to protect vascular endothelial cell, improve blood rheology, expand the peripheral microvascular, nourish the nerve with blood and oxygen supply, prevent or reverse impaired peripheral nerve fibers of DPN.

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Reference (14)

[1]	中国医师协会内分泌代谢医师分会.糖尿病周围神经病变诊疗规范(征求意见稿) [J].中国糖尿病杂志,2009,17(8):638.
[2]	中华中医药学会.糖尿病周围神经病变中医防治指南[J].中国中医药现代远程教育,2009,9(22):119.
[3]	王琪,胡良平,毛玮,等.如何把握实验设计的随机原则[J].药学服务与研究,2010,10(3):171.
[4]	管晓峰,陈智绍,黄淑玉,等.参生系列方剂在2型糖尿病慢性并发症中的临床应用[J].临床内科杂志,2002,19(增刊):142.
[5]	黄秋明,李艳,胡红艳,等.降糖合剂的薄层色谱鉴别[J].中国药师,2009,12(8):1166.
[6]	李庆,叶真,倪海祥.糖尿病周围神经病变的临床评估和诊断进展[J].浙江临床医学,2008,10(10):1388.
[7]	张先淑,胡先明.茯苓三萜化合物的药理作用及临床应用研究进展[J].重庆工贸职业技术学院学报,2011,24(4):46.
[8]	孙晓生,谢波.山药药理作用的研究进展[J].中药新药与临床药理,2011, 22 (3):353.
[9]	刘朵,章丹丹,卞卡.地黄药理药化及配伍研究[J].时珍国医国药,2012,23 (3):748.
[10]	邬浩杰.丹参的药理作用研究[J].浙江中医药大学学报,2008,32 (5):694.
[11]	罗丹冬,张会平,王沛坚,等.桂枝甘草汤提取物抗血栓形成的药效及机理的初步研究[J].新中医,2010,42 (7):109.
[12]	Mather KJ, Lteif A, Steinberg HO, et al. Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes[J]. Diabetes,2004,53(8):2060.
[13]	柴伟栋,陈家伟,沈捷,等.葡萄糖、胰岛素对内皮细胞一氧化氮和内皮素1分泌影响的对比研究[J].中华内分泌代谢杂志,2004,20(2):170.
[14]	王春梅,刘艳,王艳,等.内皮素、一氧化氮与糖尿病周围神经病变关系的研究[J].医学新知杂志,2002,12(1):10.

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Clinical efficacy of Jiangtang Mixture on diabetic peripheral Neuropathy

doi: 10.3969/j.issn.1006-0111.2013.02.012

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