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Volume 31 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(1): 64-66

XUE Zhi-hong, WANG Sheng-hao, PAN Shi-ru. Determination of doxapram hydrochloride glucose injection by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 64-66. doi: 10.3969/j.issn.1006-0111.2013.01.019
Citation: XUE Zhi-hong, WANG Sheng-hao, PAN Shi-ru. Determination of doxapram hydrochloride glucose injection by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 64-66. doi: 10.3969/j.issn.1006-0111.2013.01.019
shu

Determination of doxapram hydrochloride glucose injection by HPLC

doi: 10.3969/j.issn.1006-0111.2013.01.019

  • School of Pharmacy, Anhui Xinhua University, Hefei 230088 China

  • Received Date: 2012-04-06
  • Rev Recd Date: 2012-05-17
  • Objective To establish an HPLC method for determination of doxapram hydrochloride glucose injection. Methods COSMOSIL C18 (150 mm×4.6 mm,5 μm) column was adopted. The mobile phase consisted of 0.82 μg/L CH3COONa (using Glacial acetic acid adjust to pH 4.5)-acetonitrile (70:30). The detection wavelength was 214 nm. Results The linearity of doxapram hydrochloride concentration was in the range of 13~91 μg/ml (r=0.999 8). The average recovery was 99.3％,RSD=0.81% (n=9). Conclusion The method was simpleaccurate and sensitive with high specificity.
  • [1] 王 乐.应用拮抗药多沙普仑临床观察[J].中国医师杂志,2004,10(增刊):257.
    [2] 中国药典2010版.二部[S].2010:629.
    [3] 欧洲药典[S].第7版.1893.
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Determination of doxapram hydrochloride glucose injection by HPLC

doi: 10.3969/j.issn.1006-0111.2013.01.019
  • School of Pharmacy, Anhui Xinhua University, Hefei 230088 China
  • Received Date: 2012-04-06
  • Rev Recd Date: 2012-05-17

Abstract: Objective To establish an HPLC method for determination of doxapram hydrochloride glucose injection. Methods COSMOSIL C18 (150 mm×4.6 mm,5 μm) column was adopted. The mobile phase consisted of 0.82 μg/L CH3COONa (using Glacial acetic acid adjust to pH 4.5)-acetonitrile (70:30). The detection wavelength was 214 nm. Results The linearity of doxapram hydrochloride concentration was in the range of 13~91 μg/ml (r=0.999 8). The average recovery was 99.3％,RSD=0.81% (n=9). Conclusion The method was simpleaccurate and sensitive with high specificity.

XUE Zhi-hong, WANG Sheng-hao, PAN Shi-ru. Determination of doxapram hydrochloride glucose injection by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 64-66. doi: 10.3969/j.issn.1006-0111.2013.01.019
Citation: XUE Zhi-hong, WANG Sheng-hao, PAN Shi-ru. Determination of doxapram hydrochloride glucose injection by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 64-66. doi: 10.3969/j.issn.1006-0111.2013.01.019
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