Study on the solubility and stability of curcumin in PEG-400

TONG Yong-tao; GAO Yong; GAO Bao-an; YUE Li-qun; CHEN Jian-ming

doi:10.3969/j.issn.1006-0111.2013.01.016

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Objective To study the solubility and stability of curcumin in PEG-400 and screen the best suitable stabilizer to improve the autoclave stability. Methods Solubility determination was used to determine the solubility of curcumin in PEG-400.The stability under different pH conditions was studied by accelerated testing. The best suitable stabilizer was screened to improve the autoclave stability and the validity of the curcumin solution in PEG-400 with stabilizer was speculated by accelerated testing. Results The solubility of curcumin in PEG-400 was 42 mg/mL;the most stable pH was 3.70. The 0.1% propyl gallate could improve the sterilization stability of curcumin in PEG-400. At room temperature (25℃), the validity duration of curcumin PEG-400 solution with 0.1% propyl gallate was 296.1 days and if at low temperature (6℃), it coulb be up to 5.5 years. Conclusion The study showed that the solubility of curcumin was greatly improved and 0.1% propyl gallate could greatly improve the sterilization stability of curcumin in PEG-400.

Study on the solubility and stability of curcumin in PEG-400

1. Second Military Medical University, Department of Graduate Management, Shanghai 200433, China

2. School of Pharmacy, Shanghai 200433, China

Received Date: 2012-06-01

Rev Recd Date: 2012-10-30

Key words:

curcumin /
PEG-400 /
solubility /
autoclaving /
stability

Abstract: Objective To study the solubility and stability of curcumin in PEG-400 and screen the best suitable stabilizer to improve the autoclave stability. Methods Solubility determination was used to determine the solubility of curcumin in PEG-400.The stability under different pH conditions was studied by accelerated testing. The best suitable stabilizer was screened to improve the autoclave stability and the validity of the curcumin solution in PEG-400 with stabilizer was speculated by accelerated testing. Results The solubility of curcumin in PEG-400 was 42 mg/mL;the most stable pH was 3.70. The 0.1% propyl gallate could improve the sterilization stability of curcumin in PEG-400. At room temperature (25℃), the validity duration of curcumin PEG-400 solution with 0.1% propyl gallate was 296.1 days and if at low temperature (6℃), it coulb be up to 5.5 years. Conclusion The study showed that the solubility of curcumin was greatly improved and 0.1% propyl gallate could greatly improve the sterilization stability of curcumin in PEG-400.

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Study on the solubility and stability of curcumin in PEG-400

doi: 10.3969/j.issn.1006-0111.2013.01.016

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通讯作者: 陈斌, [email protected]

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