LOU Yue-fen, LI Ying, HU Bin. Protective effect of total flavonoids in Herba Siegesbeckiae on cerebral ischemia in rats[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 42-44. doi: 10.3969/j.issn.1006-0111.2013.01.012
| Citation:
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LOU Yue-fen, LI Ying, HU Bin. Protective effect of total flavonoids in Herba Siegesbeckiae on cerebral ischemia in rats[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 42-44. doi: 10.3969/j.issn.1006-0111.2013.01.012
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Protective effect of total flavonoids in Herba Siegesbeckiae on cerebral ischemia in rats
- Received Date: 2012-05-16
- Rev Recd Date:
2012-10-08
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Abstract
Objective To study the protective effect and possible mechanism of total flavonoids in Herba Siegesbeckiae on focal cerebral ischemia in rats. Methods Sprague Dawley (SD) rats were randomly divided into 6 groups: sham operation group, model group, total flavonoids of Herba Siegesbeckiae groups with low, moderate and high dose (5, 10, 20 mg/kg)and ginkgo leaf tablet group (50 mg/kg). Focal cerebral ischemia model was established by middle cerebral artery occlusion. The effects of Herba Siegesbeckiae total flavonoids on nervous behavior, cerebral infarct volume and the content of brain water were observed in rats. The activities of malondialdehyde (MDA), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) in cerebral tissues were measured. Results total flavonoids of Herba Siegesbeckiae could improve the neurological function, reduce the cerebral infarct volume, the content of brain water and the activity of MDA, increase the activity of SOD and GSH-Px. Conclusion Total flavonoids of Herba Siegesbeckiae could alleviate focal cerebral ischemia injury, and the mechanism might be related to anti-oxidant effect.
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