The clinical features of drug-induced liver injury in elderly

TANG Xian-feng; SUN Jie; LU Ming-zhu

doi:10.3969/j.issn.1006-0111.2013.01.006

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Drug-induced hepato-toxicity was an important reason for the liver disease in elderly,which was four times more common than in adults and might include all known liver disorders. Reports related to drug side effects were rare in people >60 years of age group since most clinical trials exclude patients >75~80 years of age. Further clinical studies should be need to investigate hepatic side effects of drugs in elderly patients. The main clinical manifestations and diagnosis of drug-induced liver injury in elderly as well as common drugs (cardiovascular drugs and anti-microbial agents) cause liver injury in clinical conditions were reviewed in this paper.

The clinical features of drug-induced liver injury in elderly

1. Shanghai Retired Cadres, General Logistics Department, Shanghai, 200437 China

2. Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

Received Date: 2012-04-25

Rev Recd Date: 2012-11-12

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Abstract: Drug-induced hepato-toxicity was an important reason for the liver disease in elderly,which was four times more common than in adults and might include all known liver disorders. Reports related to drug side effects were rare in people >60 years of age group since most clinical trials exclude patients >75~80 years of age. Further clinical studies should be need to investigate hepatic side effects of drugs in elderly patients. The main clinical manifestations and diagnosis of drug-induced liver injury in elderly as well as common drugs (cardiovascular drugs and anti-microbial agents) cause liver injury in clinical conditions were reviewed in this paper.

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The clinical features of drug-induced liver injury in elderly

doi: 10.3969/j.issn.1006-0111.2013.01.006

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通讯作者: 陈斌, [email protected]

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