Recent progress on biological activity and synthesis of 2-substituted Benzofuran derivatives

CHEN Huan; LI Ke

doi:10.3969/j.issn.1006-0111.2013.01.002

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Benzofuran derivatives were a series of attracting heterocyclic compounds with a variety of biological activity. Based on the recently published literatures, these derivatives had shown antitumor, antioxidant, calcium influx blockade, angiotensin II receptor antagonistic, adenosine A1 receptor antagonistic, antifungal, antibacterial and platelet aggregation antagonistic activities. As Benzofuran derivatives had broad activity, which had attracted many research interests. In order to better study of these compounds both in synthesis and biological activity, the review focused on the biological activity and synthetic methods of 2-substituted Benzofuran derivatives in recent years, which would provide valuable information for the development of 2-substituted benzofuran compounds.

Recent progress on biological activity and synthesis of 2-substituted Benzofuran derivatives

Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2011-03-14

Rev Recd Date: 2012-06-10

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Abstract: Benzofuran derivatives were a series of attracting heterocyclic compounds with a variety of biological activity. Based on the recently published literatures, these derivatives had shown antitumor, antioxidant, calcium influx blockade, angiotensin II receptor antagonistic, adenosine A1 receptor antagonistic, antifungal, antibacterial and platelet aggregation antagonistic activities. As Benzofuran derivatives had broad activity, which had attracted many research interests. In order to better study of these compounds both in synthesis and biological activity, the review focused on the biological activity and synthetic methods of 2-substituted Benzofuran derivatives in recent years, which would provide valuable information for the development of 2-substituted benzofuran compounds.

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Recent progress on biological activity and synthesis of 2-substituted Benzofuran derivatives

doi: 10.3969/j.issn.1006-0111.2013.01.002

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通讯作者: 陈斌, [email protected]

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