Therapeutic effects of Thesium chinensis on adriamycin-induced nephropathy rats

Key words: 
• Thesium chinensis Turcz /
• pharmacology /
• Adriamycin-induced nephritic syndrome /
• SD rats /
• TCD therapy

Abstract: Objective To investigate the therapeutic effects of Thesium chinensis Turcz on Adriamycin-induced nephropathy rats. Methods 40 SD rats were divided into 4 groups averagely:normal control group, model control group, low-dosage group (1.0 g/(kg·d) and high-dosage group(5.0 g/(kg·d). Nephritic syndrome models were established in 30 rats by intravenous injection of Adriamycin (6.0 mg/kg). The rats of low-dosage group and high-dosage group were intragastric administrated decoction of Thesium chinensis Turcz daily, the model control group rats were given running water(2 ml). During 5 weeks treatment process, the 24 hour urine volume, 24 hour urine protein concentration of rats were observed. The level of total serum protein(TP), serum albumin(ALP), total cholesterol(TCH), triglycerides(TG) and UREA were determined, and the pathological changes of kidney tissue were assayed after the therapy process. Results The symptoms of nephritic syndromes, such as edema, tail-rot disease, were relieved by Thesium chinensis Turcz. After 2 weeks therapy, the 24 hour urine volume of low-dosage group and high-dosage group were significantly higher than model control, and the 24 hour urine protein concentration were significantly lower than model control after 3 weeks. The level of TP and ALP of low-dosage group were significantly higher than model control, as well as the level of TCH and TG were significantly lower after 5 weeks. Conclusion Thesium chinensis Turcz could eliminate tissue edema and decrease the urine protein concentration by diuretic action and improves renal pathology to protect the kidney from damage by reducing the serum cholesterol level, decreased blood lipid content, and increased the plasma protein level.