LIU Hong-yue, JIANG Jian, MA Lin, LIANG Yuan-yuan, DONG Fa-jie, CUI Li-li. Penetration enhancement of electret and united Azone on cyclosporin A transdermal delivery in vitro[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 440-442,466. doi: 10.3969/j.issn.1006-0111.2012.06.012
| Citation:
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LIU Hong-yue, JIANG Jian, MA Lin, LIANG Yuan-yuan, DONG Fa-jie, CUI Li-li. Penetration enhancement of electret and united Azone on cyclosporin A transdermal delivery in vitro[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 440-442,466. doi: 10.3969/j.issn.1006-0111.2012.06.012
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Penetration enhancement of electret and united Azone on cyclosporin A transdermal delivery in vitro
- 1.
Department of Inorganic Chemistry, School of Pharmacy, Second Military University, Shanghai 200433, China
- 2.
Department of physics and Mathematics, College of Basic Medical Sciences, Second Military University, Shanghai 200433, China
- Received Date: 2012-04-24
- Rev Recd Date:
2012-09-10
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Abstract
Objective To study the penetration enhancement of electret and united Azone on cyclosporin A transdermalde livery in vitro. Methods Using corona charged -500 V, -1 000 V and -2 000 V polypropylene (PP) as electrets, 1%, 3% and 5% Azone as chemical enhancers, the transdermal behaviours of the cyclosporine A in solution were evaluated by modified Franze diffusion cell method. The concentration of cyclosporine A was measured by HPLC. Results All the electrets and chemical enhancers used in this study enhanced the cumulative penetration amount of the drug. The combination of -1 000 V and 1% Azone showed a slight increase in cumulative penetration amount of the drug compared with that of the 1% Azone used alone. Conclusion Both the negative electret and Azone could enhance the transdermal delivery of cyclosporin A individually. But negative electret and Azone had no synergistic enhancing effect on cyclosporin A transdermal delivery.
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