Progress on pharmacokinetics of lopinavir

YAO Ya-min; MU Jun; SUN Ji; MA Fang; LU Hong-zhou; ZHANG Li-jun

doi:10.3969/j.issn.1006-0111.2012.05.005

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Lopinavir was widely used as a second generation protease inhibitor in AIDS therapy, which was quickly metabolized by CYP3A4. For individual variance might lead to different metabolism, it was important to study the pharmacokinetic parameters of lopinavir and learn the relationship between drug concentration and curative effect or adverse reactions. The methods for determining lopinavir concentration and the progress of pharmacokinetic research were reviewed in this paper which might offer some help for treatment drug monitoring (TDM) and personalized dosage research.

Progress on pharmacokinetics of lopinavir

1. Shanghai Public Health Clinical Center, Shanghai 201508, China

2. Medical College of Suzhou University, Suzhou 215123, China

Received Date: 2011-12-06

Rev Recd Date: 2012-01-14

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Abstract: Lopinavir was widely used as a second generation protease inhibitor in AIDS therapy, which was quickly metabolized by CYP3A4. For individual variance might lead to different metabolism, it was important to study the pharmacokinetic parameters of lopinavir and learn the relationship between drug concentration and curative effect or adverse reactions. The methods for determining lopinavir concentration and the progress of pharmacokinetic research were reviewed in this paper which might offer some help for treatment drug monitoring (TDM) and personalized dosage research.

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Progress on pharmacokinetics of lopinavir

doi: 10.3969/j.issn.1006-0111.2012.05.005

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通讯作者: 陈斌, [email protected]

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