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Volume 30 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(3): 211-212,215

BAO Lei-lei, CHEN Hai-fei, BIAN Jun, YUAN Bing. The effect of Jianbu Guanjie Capusule on level of correlative ingredients in osteoarthropathy model of rabbit[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 211-212,215. doi: 10.3969/j.issn.1006-0111.2012.03.014
Citation: BAO Lei-lei, CHEN Hai-fei, BIAN Jun, YUAN Bing. The effect of Jianbu Guanjie Capusule on level of correlative ingredients in osteoarthropathy model of rabbit[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 211-212,215. doi: 10.3969/j.issn.1006-0111.2012.03.014
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The effect of Jianbu Guanjie Capusule on level of correlative ingredients in osteoarthropathy model of rabbit

doi: 10.3969/j.issn.1006-0111.2012.03.014

  • Department of Pharmacy, NO.411 Hospital of PLA,Shanghai 200434,China

  • Received Date: 2012-03-09
  • Rev Recd Date: 2012-04-11
  • Objective To discuss the protection and mechanism of Jianbu Guanjie Capusule( JBGJ capsule) to the knee osteoarthritis of rabbit. Methods Thirty healthy New Zealand rabbits were divided into five groups randomly with parallel control methods.The five groups were model group, positive group, low dose group, middle dose group and high dose group, respectively.The osteoarthropathy of knee joint model was built according to the Japanese KangYan standard.The rabbits were given the drug in the next day after the model establishment. After six weeks, animal serum and slippery membranes were collected to be detected. Results The activity of SOD in serum was improved in the middle, high dose group and positive group, which had significant different with the model group(P<0.05).The nitric oxide (NO) in serum was raised in low, middle and high dose group. The middle dose group had significant different with the model group. Conclusion JBGJ capsule could improve the activity of Superoxide dismutase (SOD) in serum and the level of NO, which could obviously improved the pathological alteration in osteoarthropathy model of rabbit.
  • [1] 梁 平,李胜利,方苏亭,等.骨炎痛定方对实验性兔膝关节病血清中NO和SOD含量的影响[J].中国中医骨科杂志,2006,14(6):50.
    [2] 沈有亮,邓伟民,韦 嵩,等.补肾壮骨中药对去势雌性大鼠胫骨上端细胞立体计量学的影响[J].中国临床康复,2006,27(1):42.
    [3] 茹靖涛,曹 靖,任秀花,等.硫酸氨基葡萄糖对佐剂关节炎大鼠镇痛作用及IL-6表达影响[J].中国医疗前沿,2010,(5):20.
    [4] Reginster JY,Bruyere O,Neuprez A.Current role of glucosamine in the treatment of osteoarthritis[J].Rheumatology(Oxford),2007,46(5):731.
    [5] Scholtissen S, Bruyère O, Neuprez A, et al. Glucosamine sulphate in the treatment of knee osteoarthritis:costeffectiveness comparison with paracetamol[J].Int J Clin Pract,2010,64(6):756.
    [6] Wei XQ, Wright GC, Sokoloff L.The effect of sodium selenite on chondrocyes in monolayer culture[J].Authritis Rheum,1996, 29(11):660.
    [7] 茅文斌,邵增务.一氧化氮与骨性关节炎研究进展[J].国际骨科学杂志,2006,27(4):232.
    [8] Fermor B,Weinberg JB,Pisetsky DS,et al.Effect of cyclic mechanical strain and tumor necrosis factor alpha on the response of cells of the meniscus[J].Osteoarthritis Cartilage,2004,12 (12):974.
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The effect of Jianbu Guanjie Capusule on level of correlative ingredients in osteoarthropathy model of rabbit

doi: 10.3969/j.issn.1006-0111.2012.03.014
  • Department of Pharmacy, NO.411 Hospital of PLA,Shanghai 200434,China
  • Received Date: 2012-03-09
  • Rev Recd Date: 2012-04-11

Abstract: Objective To discuss the protection and mechanism of Jianbu Guanjie Capusule( JBGJ capsule) to the knee osteoarthritis of rabbit. Methods Thirty healthy New Zealand rabbits were divided into five groups randomly with parallel control methods.The five groups were model group, positive group, low dose group, middle dose group and high dose group, respectively.The osteoarthropathy of knee joint model was built according to the Japanese KangYan standard.The rabbits were given the drug in the next day after the model establishment. After six weeks, animal serum and slippery membranes were collected to be detected. Results The activity of SOD in serum was improved in the middle, high dose group and positive group, which had significant different with the model group(P<0.05).The nitric oxide (NO) in serum was raised in low, middle and high dose group. The middle dose group had significant different with the model group. Conclusion JBGJ capsule could improve the activity of Superoxide dismutase (SOD) in serum and the level of NO, which could obviously improved the pathological alteration in osteoarthropathy model of rabbit.

BAO Lei-lei, CHEN Hai-fei, BIAN Jun, YUAN Bing. The effect of Jianbu Guanjie Capusule on level of correlative ingredients in osteoarthropathy model of rabbit[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 211-212,215. doi: 10.3969/j.issn.1006-0111.2012.03.014
Citation: BAO Lei-lei, CHEN Hai-fei, BIAN Jun, YUAN Bing. The effect of Jianbu Guanjie Capusule on level of correlative ingredients in osteoarthropathy model of rabbit[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 211-212,215. doi: 10.3969/j.issn.1006-0111.2012.03.014
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