Study on pharmacokinetics and relative bioavailability of nimodipine orally disintegrating tablet

GAO Yue; YANG Ling; WU Rong

doi:10.3969/j.issn.1006-0111.2012.03.011

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Objective To research the pharmacokinetics and relative bioavailability of Nimodipine rapid disintegeating tablet in human body, which was compared with Nimodipine market tablets. Methods 6 cases of health volunteer were divide into two groups randomly , alternately taking rapid disintegeating tablet A and market tablet B of Nimodipine 60mg single dosage orally, HPLC was used to determine the concentration of Nimodipine in blood. Results The main Pharmacokinetics parameters after single oral administration Nimodipine rapid disintegeating tablet A and Nimodipine market tablet B were (256.23±54.64) g/ml, (102.415±36.96) g/ml in C_max; (0.7049±0.035) h, (1.3317±0.123) h in T_max; (0.2734±0.031) h, (1.1958±0.141) h in T_1/2; (622.77±98.03) g/(ml·h), (354.63±96.24) g/(ml·h) in AUC_{0 - t}, respectively. The bioavailability of rapid disintegeating tablet was 177.27% relative to market tablet. Conclusion Nimodipine rapid disintegeating tablet was capable of releasing rapidly, and had an enhanced bioavailability as compared with market tablet.

Study on pharmacokinetics and relative bioavailability of nimodipine orally disintegrating tablet

School of pharmacy, Second Military Medical University, Shanghai 200433,China

Received Date: 2010-04-14

Rev Recd Date: 2010-07-16

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Abstract: Objective To research the pharmacokinetics and relative bioavailability of Nimodipine rapid disintegeating tablet in human body, which was compared with Nimodipine market tablets. Methods 6 cases of health volunteer were divide into two groups randomly , alternately taking rapid disintegeating tablet A and market tablet B of Nimodipine 60mg single dosage orally, HPLC was used to determine the concentration of Nimodipine in blood. Results The main Pharmacokinetics parameters after single oral administration Nimodipine rapid disintegeating tablet A and Nimodipine market tablet B were (256.23±54.64) g/ml, (102.415±36.96) g/ml in C_max; (0.7049±0.035) h, (1.3317±0.123) h in T_max; (0.2734±0.031) h, (1.1958±0.141) h in T_1/2; (622.77±98.03) g/(ml·h), (354.63±96.24) g/(ml·h) in AUC_{0 - t}, respectively. The bioavailability of rapid disintegeating tablet was 177.27% relative to market tablet. Conclusion Nimodipine rapid disintegeating tablet was capable of releasing rapidly, and had an enhanced bioavailability as compared with market tablet.

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Reference (7)

[1]	Zendelovska D,Stafilov T,Stefova M.Optimization of a solid-phase extraction method for determination of indapamide in biological fluids using high-performance liquid chromatography[J].J Chromatogr B,2003,788(1):199.
[2]	张莉,李昕.RP-HPLC法测定血浆中尼莫地平浓度[J].中国药师,2004,7(11):865.
[3]	邝荔香,丁黎. GC法测定血浆中尼莫地平浓度及药动学研究[J].安徽医科大学学报,2000,35(3):191.
[4]	Jain DS,Subbaiah G,Sanyal M,et al.Liquid chromatography tandem mass spectrometry validated method for the estimation of indapamide in human whole blood[J].J Chromatogr B,2006,834(1):149.
[5]	Hang TJ,Zhao W,Liu J,et al.A selective HPLC method for the determination of indapamide in human whole blood:Application to a bioequivalence study in Chinese volunteers[J].J Pharm Biomed Anal,2006,40:202.
[6]	缪海均,刘皋林,范国荣,等.尼莫地平胶丸的人体药代动力学及相对生物利用度研究[J].第二军医大学学报,2003,24(12):1371.
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[1]	Zendelovska D,Stafilov T,Stefova M.Optimization of a solid-phase extraction method for determination of indapamide in biological fluids using high-performance liquid chromatography[J].J Chromatogr B,2003,788(1):199.
[2]	张莉,李昕.RP-HPLC法测定血浆中尼莫地平浓度[J].中国药师,2004,7(11):865.
[3]	邝荔香,丁黎. GC法测定血浆中尼莫地平浓度及药动学研究[J].安徽医科大学学报,2000,35(3):191.
[4]	Jain DS,Subbaiah G,Sanyal M,et al.Liquid chromatography tandem mass spectrometry validated method for the estimation of indapamide in human whole blood[J].J Chromatogr B,2006,834(1):149.
[5]	Hang TJ,Zhao W,Liu J,et al.A selective HPLC method for the determination of indapamide in human whole blood:Application to a bioequivalence study in Chinese volunteers[J].J Pharm Biomed Anal,2006,40:202.
[6]	缪海均,刘皋林,范国荣,等.尼莫地平胶丸的人体药代动力学及相对生物利用度研究[J].第二军医大学学报,2003,24(12):1371.
[7]	梁文权. 生物药剂学与药物动力学[M]北京:人民卫生出版社,2004:266.

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Study on pharmacokinetics and relative bioavailability of nimodipine orally disintegrating tablet

doi: 10.3969/j.issn.1006-0111.2012.03.011

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通讯作者: 陈斌, [email protected]

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