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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(3): 189-193

WU Hao, SONG Hong-tao. Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 189-193. doi: 10.3969/j.issn.1006-0111.2012.03.009
Citation: WU Hao, SONG Hong-tao. Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 189-193. doi: 10.3969/j.issn.1006-0111.2012.03.009
shu

Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension

doi: 10.3969/j.issn.1006-0111.2012.03.009
  • 1.

    Department of Pharmacy, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025,China;Department of Pharmacy, General Hospital of Nanjing Military Region, Fuzhou 350025,China

  • 2.

    Department of Pharmacy, General Hospital of Nanjing Military Region, Fuzhou 350025,China

  • Received Date: 2012-02-14
  • Rev Recd Date: 2012-03-23
  • Objective To optimize the preparation and study in vitro releasing of SRL-NLC dispersion. Methods Central composite design-response surface methodology was used to optimize dispersion formulation,then in vitro releasing in 0.4% SDS(sodium lauryl sulfate) solution was explored by normal phase dialysis bag method. Results The optimal dispersion had PS(particle size):82.54nm,PI(polydisperity index):0.207, Zeta potential: -18.0 mv,DL (drug-loading): 1.829%, and EE(entrapment efficiency): 91.3%; SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4%SDS solution. Conclusion The optimal formulation had good feasibility and reproducibility, in vitro releasing curve showed SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4% SDS solution.
  • [1] 梁文权.生物药剂学与药物动力学[M].第3版.北京:人民教育出版社,2007:50.
    [2] Zhuang CY,Li N,Wang M,et al. Preparation and characterization of vinpocetine loaded nanostructured lipid carriers(NLC) for improved oral bioavailiability[J]. Int J Pharm,2010(394):183.
    [3] Zhang ZW,Bu HH,Gao ZW,et al. The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats[J]. Int J Pharm,2010(394):149.
    [4] Natalie LT,William NC,Christopher JHP. Lipid-based delivery systems and intestinal lymphatic drug transport:A mechanistic update[J]. Adv Drug Deli Rev,2008(60):712.
    [5] 王 娟,张 晶,宋洪涛,等. 西罗莫司单层高分子渗透泵控释片的制备及其体外释放特性研究[J]. 中国药房,2010,21(37):3503.
    [6] David JH.Oral lipid-based formulations[J]. Adv Drug Deli Rev,2007(59):668.
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Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension

doi: 10.3969/j.issn.1006-0111.2012.03.009
  • 1. Department of Pharmacy, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025,China;Department of Pharmacy, General Hospital of Nanjing Military Region, Fuzhou 350025,China
  • 2. Department of Pharmacy, General Hospital of Nanjing Military Region, Fuzhou 350025,China
  • Received Date: 2012-02-14
  • Rev Recd Date: 2012-03-23

Abstract: Objective To optimize the preparation and study in vitro releasing of SRL-NLC dispersion. Methods Central composite design-response surface methodology was used to optimize dispersion formulation,then in vitro releasing in 0.4% SDS(sodium lauryl sulfate) solution was explored by normal phase dialysis bag method. Results The optimal dispersion had PS(particle size):82.54nm,PI(polydisperity index):0.207, Zeta potential: -18.0 mv,DL (drug-loading): 1.829%, and EE(entrapment efficiency): 91.3%; SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4%SDS solution. Conclusion The optimal formulation had good feasibility and reproducibility, in vitro releasing curve showed SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4% SDS solution.

WU Hao, SONG Hong-tao. Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 189-193. doi: 10.3969/j.issn.1006-0111.2012.03.009
Citation: WU Hao, SONG Hong-tao. Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 189-193. doi: 10.3969/j.issn.1006-0111.2012.03.009
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