Progress on extracellularly activated nanocarriers

WANG Xiao-yu; GAO Jing; ZHANG Wei; ZHU Quan-gang; WU Xin; GAO Shen

doi:10.3969/j.issn.1006-0111.2012.01.002

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

Both the stealth and targeting features were important for effective and selective drug delivery to the tumors.However, it was difficult to achieve both features simultaneously. Some of the novel targeting strategies had the potential to overcome this challenge. The new targeting technologies with recent examples were reviewed, which utilized the environmental stimuli to activate the nanocarriers. Traditional strategies for tumor-targeted nanocarriers were briefly discussed with an emphasis on their achievements and challenges.

Progress on extracellularly activated nanocarriers

1. Department of Pharmacy,Changhai Hosptial,Second Military Medical University,Shanghai 200433, China

2. Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433,China

3. The 522th Hospital of PLA,Luoyang,Henan 471003,China

Received Date: 2011-05-07

Rev Recd Date: 2011-06-02

Key words:

Abstract: Both the stealth and targeting features were important for effective and selective drug delivery to the tumors.However, it was difficult to achieve both features simultaneously. Some of the novel targeting strategies had the potential to overcome this challenge. The new targeting technologies with recent examples were reviewed, which utilized the environmental stimuli to activate the nanocarriers. Traditional strategies for tumor-targeted nanocarriers were briefly discussed with an emphasis on their achievements and challenges.

HTML

Reference (26)

[1]	Maeda H,Wu J,Sawa T,et al.Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review[J]. J Control Release, 2000,65(1-2): 271.
[2]	Yang T, Choi MK,Cui FD,et al.Preparation and evaluation of paclitaxel-loaded PEGylated immunoliposome[J]. J Control Release, 2007,120(3): 169.
[3]	Wang Y, Drummond DC,SHao Y,et al.Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines[J]. Int J Pharm, 2007. 337(1-2): 63.
[4]	Dagar S, Drummond DC,Noble CO,et al.VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies[J]. J Control Release, 2003,91(1-2): 123.
[5]	Allen T M. and P.R. Cullis, Drug delivery systems: entering the mainstream. Science, 2004,303(5665): 1818.
[6]	Hobbs, S.K, et al.Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment[J]. Proc Natl Acad Sci U S A, 1998,95(8): 4607.
[7]	Heldin, C.H, et al.High interstitial fluid pressure-an obstacle in cancer therapy[J]. Nat Rev Cancer, 2004,4(10): 806.
[8]	Gabizon, A, et al.In vivo fate of folate-targeted polyethylene-glycol liposomes in tumor-bearing mice[J]. Clin Cancer Res, 2003,9(17): 6551.
[9]	Gryparis, E.C, et al.Anticancer activity of cisplatin-loaded PLGA-mPEG nanoparticles on LNCaP prostate cancer cells[J]. Eur J Pharm Biopharm, 2007. 67(1): 1.
[10]	Gabizon, A.A, H. Shmeeda, and S. Zalipsky, Pros and cons of the liposome platform in cancer drug targeting[J]. J Liposome Res, 2006,16(3): 175.
[11]	Gerweck, L.E. and K. Seetharaman, Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res, 1996,56(6): 1194.
[12]	Egeblad, M. and Z. Werb, New functions for the matrix metalloproteinases in cancer progression[J]. Nat Rev Cancer, 2002,2(3): 161.
[13]	van Sluis, R, et al.In vivo imaging of extracellular pH using 1H MRSI. Magn Reson Med, 1999,41(4): 743.
[14]	Stubbs, M, et al.Causes and consequences of tumour acidity and implications for treatment[J]. Mol Med Today, 2000,6(1):15.
[15]	Yamagata, M, et al.The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase[J]. Br J Cancer, 1998,77(11): 1726.
[16]	Mohajer, G., E.S. Lee, and Y.H. Bae, Enhanced intercellular retention activity of novel pH-sensitive polymeric micelles in wild and multidrug resistant MCF-7 cells[J]. Pharm Res, 2007,24(9): 1618.
[17]	Ko, J., et al.Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(beta-amino ester) block copolymer micelles for cancer therapy[J]. J Control Release, 2007,123(2): 109.
[18]	Lee, E.S, et al.Tumor pH-responsive flower-like micelles of poly(L-lactic acid)-b-poly(ethylene glycol)-b-poly(L-histidine)[J]. J Control Release, 2007. 123(1): 19.
[19]	Lee, E.S, et al.Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance[J]. J Control Release, 2008,129(3): 228.
[20]	Sawant, R.M,et al."SMART"drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers[J]. Bioconjug Chem, 2006,17(4): 943.
[21]	Sethuraman, V.A. and Y.H. Bae, TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors[J]. J Control Release, 2007,118(2): 216.
[22]	Kessenbrock, K, V. Plaks, and Z. Werb, Matrix metalloproteinases: regulators of the tumor microenvironment[J]. Cell, 2010,141(1): 52.
[23]	Chau, Y., F.E. Tan, and R. Langer. Synthesis and characterization of dextran-peptide-methotrexate conjugates for tumor targeting via mediation by matrix metalloproteinase II and matrix metalloproteinase IX[J]. Bioconjug Chem, 2004,15(4): 931.
[24]	Chau, Y, et al.Antitumor efficacy of a novel polymer-peptide-drug conjugate in human tumor xenograft models[J]. Int J Cancer, 2006,118(6): 1519.
[25]	Hatakeyama, H, et al.Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipi[J]d. Gene Ther, 2007,14(1): 68.
[26]	Mok, H, et al.PEGylated and MMP-2 specifically dePEGylated quantum dots: comparative evaluation of cellular uptake[J]. Langmuir, 2009,25(3): 1645.

Message Board

Progress on extracellularly activated nanocarriers

doi: 10.3969/j.issn.1006-0111.2012.01.002

Abstract

References

Proportional views

通讯作者: 陈斌, [email protected]

Article Metrics

Related

Proportional views