| [1] | ZHENG Y H, YIN L H, GRAHN T H, et al. Anticancer effects of baicalein on hepatocellular carcinoma cells[J]. Phytother Res,2014,28(9):1342-1348. doi: 10.1002/ptr.5135 |
| [2] | LIU H, DONG Y H, GAO Y T, et al. The fascinating effects of baicalein on cancer: a review[J]. Int J Mol Sci,2016,17(10):1681. doi: 10.3390/ijms17101681 |
| [3] | 马兴聪, 高晓燕, 闫婉君, 等. 黄芩素抗肿瘤机制的研究现状及最新进展[J]. 西部医学, 2016, 28(3):430-436. doi: 10.3969/j.issn.1672-3511.2016.03.038 |
| [4] | ZHAO Z X, LIU B J, SUN J, et al. Baicalein inhibits orthotopic human non-small cell lung cancer xenografts via src/Id1 pathway[J]. Evid Based Complement Alternat Med,2019,2019:9806062. |
| [5] | GAO J Y, MORGAN W A, SANCHEZ-MEDINA A, et al. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells[J]. Toxicol Appl Pharmacol,2011,254(3):221-228. doi: 10.1016/j.taap.2011.03.016 |
| [6] | SU G F, CHEN H, SUN X H. Baicalein suppresses non small cell lung cancer cell proliferation, invasion and Notch signaling pathway[J]. Cancer Biomark,2018,22(1):13-18. doi: 10.3233/CBM-170673 |
| [7] | LEUNG H W, YANG W H, LAI M Y, et al. Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis[J]. Food Chem Toxicol,2007,45(3):403-411. doi: 10.1016/j.fct.2006.08.021 |
| [8] | LU C Y, WANG H Q, CHEN S S, et al. Baicalein inhibits cell growth and increases cisplatin sensitivity of A549 and H460 cells via miR-424-3p and targeting PTEN/PI3K/Akt pathway[J]. J Cell Mol Med,2018,22(4):2478-2487. doi: 10.1111/jcmm.13556 |
| [9] | LU L W, ZHANG M F, WANG X Y, et al. Baicalein enhances the antitumor efficacy of docetaxel on nonsmall cell lung cancer in a β-catenin-dependent manner[J]. Phytother Res,2020,34(1):104-117. doi: 10.1002/ptr.6501 |
| [10] | DING Q, BAO J L, ZHAO W W, et al. Natural autophagy regulators in cancer therapy: a review[J]. Phytochem Rev,2015,14(1):137-154. doi: 10.1007/s11101-014-9339-3 |
| [11] | BIE B B, SUN J, LI J, et al. Baicalein, a natural anti-cancer compound, alters microRNA expression profiles in bel-7402 human hepatocellular carcinoma cells[J]. Cell Physiol Biochem,2017,41(4):1519-1531. doi: 10.1159/000470815 |
| [12] | KE M Y, ZHANG Z H, XU B Y, et al. Baicalein and baicalin promote antitumor immunity by suppressing PD-L1 expression in hepatocellular carcinoma cells[J]. Int Immunopharmacol,2019,75:105824. doi: 10.1016/j.intimp.2019.105824 |
| [13] | YU X L, TANG W, YANG Y C, et al. Long noncoding RNA NKILA enhances the anti-cancer effects of baicalein in hepatocellular carcinoma via the regulation of NF-κB signaling[J]. Chem Biol Interact,2018,285:48-58. doi: 10.1016/j.cbi.2018.02.027 |
| [14] | KRISTIANSEN G, SAMMAR M, ALTEVOGT P. Tumour biological aspects of CD24, a mucin-like adhesion molecule[J]. J Mol Histol,2004,35(3):255-262. |
| [15] | HAN Z Q, ZHU S M, HAN X, et al. Baicalein inhibits hepatocellular carcinoma cells through suppressing the expression of CD24[J]. Int Immunopharmacol,2015,29(2):416-422. doi: 10.1016/j.intimp.2015.10.021 |
| [16] | WANG Y F, LI T, TANG Z H, et al. Baicalein triggers autophagy and inhibits the protein kinase B/mammalian target of rapamycin pathway in hepatocellular carcinoma HepG2 cells[J]. Phytother Res,2015,29(5):674-679. doi: 10.1002/ptr.5298 |
| [17] | WANG Z X, JIANG C P, CHEN W B, et al. Baicalein induces apoptosis and autophagy via endoplasmic Reticulum stress in hepatocellular carcinoma cells[J]. Biomed Res Int,2014,2014:732516. |
| [18] | HAVERMANN S, CHOVOLOU Y, HUMPF H U, et al. Modulation of the Nrf2 signalling pathway in Hct116 colon carcinoma cells by baicalein and its methylated derivative negletein[J]. Pharm Biol,2016,54(9):1491-1502. doi: 10.3109/13880209.2015.1104703 |
| [19] | WANG L, LING Y, CHEN Y, et al. Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells[J]. Cancer Lett,2010,297(1):42-48. doi: 10.1016/j.canlet.2010.04.022 |
| [20] | CHEN Y, HONG D Y, WANG J, et al. Baicalein, unlike 4-hydroxytamoxifen but similar to G15, suppresses 17β-estradiol-induced cell invasion, and matrix metalloproteinase-9 expression and activation in MCF-7 human breast cancer cells[J]. Oncol Lett,2017,14(2):1823-1830. doi: 10.3892/ol.2017.6298 |
| [21] | GAO X Y, XUE X H, MA Y N, et al. Effect of baicalein on the expression of SATB1 in human breast cancer cells[J]. Exp Ther Med,2015,9(5):1665-1669. doi: 10.3892/etm.2015.2329 |
| [22] | CHUNG H, CHOI H S, SEO E K, et al. Baicalin and baicalein inhibit transforming growth factor-β1-mediated epithelial-mesenchymal transition in human breast epithelial cells[J]. Biochem Biophys Res Commun,2015,458(3):707-713. doi: 10.1016/j.bbrc.2015.02.032 |
| [23] | ZHAO X X, QU J K, LIU X, et al. Baicalein suppress EMT of breast cancer by mediating tumor-associated macrophages polarization[J]. Am J Cancer Res,2018,8(8):1528-1540. |
| [24] | MA X C, YAN W J, DAI Z J, et al. Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway[J]. Drug Des Devel Ther,2016,10:1419-1441. |
| [25] | NGUYEN L T, SONG Y W, CHO S K. Baicalein inhibits epithelial to mesenchymal transition via downregulation of Cyr61 and LOXL-2 in MDA-MB231 breast cancer cells[J]. Mol Cells,2016,39(12):909-914. doi: 10.14348/molcells.2016.0243 |
| [26] | DOU J, WANG Z, MA L, et al. Baicalein and baicalin inhibit colon cancer using two distinct fashions of apoptosis and senescence[J]. Oncotarget,2018,9(28):20089-20102. doi: 10.18632/oncotarget.24015 |
| [27] | WANG Y X, BIAN L, CHAKRABORTY T, et al. Construing the biochemical and molecular mechanism underlying the in vivo and in vitro chemotherapeutic efficacy of ruthenium-baicalein complex in colon cancer[J]. Int J Biol Sci,2019,15(5):1052-1071. doi: 10.7150/ijbs.31143 |
| [28] | SU M Q, ZHOU Y R, RAO X, et al. Baicalein induces the apoptosis of HCT116 human colon cancer cells via the upregulation of DEPP/Gadd45a and activation of MAPKs[J]. Int J Oncol,2018,53(2):750-760. |
| [29] | LI H L, ZHANG S, WANG Y, et al. Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells[J]. Mol Med Rep,2013,7(1):266-270. doi: 10.3892/mmr.2012.1123 |
| [30] | CHOI E O, PARK C, HWANG H J, et al. Baicalein induces apoptosis via ROS-dependent activation of caspases in human bladder cancer 5637 cells[J]. Int J Oncol,2016,49(3):1009-1018. doi: 10.3892/ijo.2016.3606 |
| [31] | GEYBELS M S, VERHAGE B A, ARTS I C, et al. Dietary flavonoid intake, black tea consumption, and risk of overall and advanced stage prostate cancer[J]. Am J Epidemiol,2013,177(12):1388-1398. doi: 10.1093/aje/kws419 |
| [32] | ARYAL P, KIM K, PARK P H, et al. Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells[J]. FEBS J,2014,281(20):4644-4658. doi: 10.1111/febs.12969 |
| [33] | HUANG Y, HU J D, ZHENG J, et al. Down-regulation of the PI3K/Akt signaling pathway and induction of apoptosis in CA46 Burkitt lymphoma cells by baicalin[J]. J Exp Clin Cancer Res,2012,31:48. doi: 10.1186/1756-9966-31-48 |